The BrightSpec Advantage

BrightSpec FT-MRR (Fourier Transform-Molecular Rotational Resonance) spectrometers directly identify and quantify polar components in complex chemical mixtures using high resolution spectroscopy, achieving unparalleled molecular specificity without matrix interferences. Molecules are characterized in the isolated gas phase through a characteristic fingerprint spectral pattern that is completely unique to its three-dimensional structure. FT-MRR is a powerful complement to existing techniques for gas, volatiles, and chiral characterization and analysis, greatly shortening method development times and allowing scientists to understand their chemistry more rapidly.

FT-MRR Spectrometers

BrightSpec offers the first commercial, easy-to-use FT-MRR spectrometers for both industrial and academic research applications. Whether your application requires a broad search for unknown compounds, or targeted monitoring of a small set of known components, the flexibility of BrightSpec’s software interface allows you to get the information you need from your sample. As a spectroscopy technique, there are few consumables and few routine maintenance procedures necessary. The operation environment ranges from full-featured R&D method development to push-button operation for technicians. The FT-MRR technique provides faster chemical analysis insights for new product R&D and process development scientists.

New Discovery Targeted Diastereomer/Enantiomer Analyzer

Introduced in field trials completed in early 2018, the BrightSpec Discovery FT-MRR Diastereomer/Enantiomer Analyzer is for chiral and diastereomer process monitoring.  It uses a Fabry-Perot cavity for enhanced sensitivity in targeted monitoring.cavity-targeted-rendering-2106-09-12 Sample introduction is directly from a continuous synthesis manufacturing process, without prior sample preconditioning, drying or separation.

      • Diastereomer and enantiomer quantification in 18 minute cycle times.
      • No sample prep required–direct, in-the-mixture monitoring
      • Chiral reaction process monitoring
      • Uses Argon or neon as a carrier gas

BrightSpec One – FT-MRR High Throughput Sample Analyzer


The BrightSpec One FT-MRR characterizes the chemical composition of complex mixtures.  It rapidly delivers identification and quantitation, without the need for purification or separation. “Dirty” liquids, headspace samples, solids, and gas mixtures are volatilized using the BrightSpec HSM3 head space module, and introduced directly into the integrated sample cell.  With high specificity and dynamic range, FT-MRR identifies trace level sample components without risk of matrix interference.  There are several sampling accessories for gas sampling, headspace analysis, thermal evolution of solids, and direct volatilization of liquids. (Again, no GC step is needed). Integration with an optional CTC-PAL3 autosampler enables walk-away operation and high sample throughput rates.

      • High selectivity: ID muliple components in complex matrices
      • High dynamic range: Resolve trace components in complex matrices
      • Baseline resolution: Simple pattern matching for chemical ID
      • High specificity: Low false positive ID rates
      • Quantitative: Band intensity directly proportional to abundance
      • Rapid data acquisition rates: Minutes for full spectrum to seconds for specific bands.
      • Top pharmaceutical applications:
        1. Residual Solvent Analysis (USP <467>)
        2. Mutagenic Impurities (ICH-M7)
        3. Water Analysis (USP <921>)
        4. Ethylene Oxide (USP <228>)

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New K-Band BrightSpec Discovery MRR for Education & Research

New in 2017, the BrightSpec Discovery K-Band (18 -26.5 GHz) spectrometer is designed for both fundamental research and educational applications. The reconfigurable Discovery form factor allows customers to integrate custom sample chambers, including pulsed and CW jet flows, for studies of complexes and transient species. The instrument is operated by a laptop computer, and includes BrightSpec Edgar software for experiment setup, data visualization and k-band-instrument-home-pageprocessing, and spectral library comparison. The instrument usability, capabilities, and cost make it suitable for incorporation into undergraduate teaching curricula.

      • For academic research and undergraduate teaching laboratories
      • 18 -26.5 GHz frequency coverage
      • Easily reconfigured for different sample chamber designs
      •  Four marker channel outputs for synchronization to external devices
      •  Targeted and segmented chirped-pulse acquisition modes
      •  Advanced pulse sequences, including double resonance and echoes (in development)
      •  Expandable spectral library—for experiment data and simulations
      •  Automated composition analysis software for quantitative mixture analysis
      •  Standard 110/220 volt power

W-Band BrightSpec Discovery – FT-MRR for Fundamental Research

r-seriesBrightSpec Discovery incorporates the same spectroscopic engine as BrightSpec One. The difference is in its form factor, with Discovery employing a modular design for increased experimental flexibility. It operates in identical fashion to the BrightSpec One, but can be combined with and networked to other analytical systems. This thoughtful approach to customization enables fundamental and applied research groups to quickly generate insights on complex processes.

      • Shares the fundamental attributes of BrightSpec One
          Broad analytical capabilities
      • Removable sample chamber
          Easy integration of custom sample cells
      • Interchangeable excitation source
          Limited frequency flexibility
      • Direct signal access for broadband monitoring and digitization
          Implement complex custom data collection sequences
      • Full integration with Edgar data collection and analysis software suite
          Maintains ease of use

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BrightSpec Chiral Broadband – FT-MRR for Chiral Characterization

BrightSpec Chiral Broadband is an FT-MRR platform used to differentiate diastereomers in mixtures without preparatory purification or separation. With the addition of the optional 3-Wave Mixing technology, enantiomeric excess may be determined. Operating in the microwave frequency range, and using pulsed jet nozzles to prepare rotationally cooled samples, this alternative to chromatography offers a combination of high-resolution, spectrally specific analyses for chiral characterization.

      • Spectra relate directly to structure
          Bond angle
          Bond lengths
      • High specificity
          Easily distinguish between conformers
      • Can analyze complex mixtures
          No need for pure samples
      • Chiral analysis
      • With addition of 3-Wave mixing technology
          Enantiomeric excess

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Recent News

University of Texas Rio Grande Valley Acquires BrightSpec Spectrometer

Charlottesville, VA—Feb 8, 2018— BrightSpec announced today the sale of a BrightSpec MRR Discovery K-band spectromet...

BrightSpec and Cornes Technologies Conclude Demo and Symposium in Japan

Charlottesville, VA—Jan 15, 2018— BrightSpec announced today the successful conclusion of a demonstration of the Bri...

BrightSpec Tests Continuous Reaction Monitoring in Collaboration with UVA and VCU Medicines for All Institute

Charlottesville, VA—December 20, 2017— BrightSpec, in collaboration with research groups at Virginia Commonwealth Un...

BrightSpec Completes First Dual-Band 260-290/520-580 GHz MRR Spectrometer

Charlottesville, VA—Dec 15, 2017— BrightSpec announced today the completion of a new instrument for chemical analysi...

BrightSpec and Cornes Technologies Announce Distribution Agreement

Charlottesville, VA and Tokyo, Japan, August 18, 2017 –BrightSpec, the MRR spectroscopy company, announced the appoint...

BrightSpec Announces Successful Field Trial for Diastereomer Analysis

Charlottesville, VA—July 7, 2017—BrightSpec, the first company to commercialize chemical analyzers based on molecula...